Multicenter Study of Quantitative SPECT: Reproducibility of ^99mTc Quantitation Using a Conjugated-Gradient Minimization Reconstruction Algorithm

This multicenter study aimed to determine the reproducibility of quantitative SPECT images reconstructed using a commercially available method ordered-subset conjugate-gradient minimization. Methods: A common cylindric phantom containing 100 kBq/mL concentration 99mTc-pertechnetate solution in volume 7 L was scanned under standard imaging conditions at 6 institutions local clinical protocol each. Interinstitutional variation among evaluated coefficient variation. Dose calibrator accuracy also investigated by measuring same lot 99mTc vials each institution. Results: The respective radioactivity concentrations and ranged from 95.71 ± 0.60 (mean SD) 108.35 0.36 96.78 0.64 108.49 0.11 kBq/mL, respectively. 4.20%. bias associated with dose Conclusion: reconstruction is high comparable that PET, for comparatively large (∼7 L), homogeneous objects.